Antimicrobial evaluation of the Patchouli (Pogostemon cablin Benth.) leaf essential oil combination with standard antimicrobial compounds

Pogostemon cablin Benth's leaves, which belong to the Lamiaceae family, are used make patchouli essential oil (PEO). Sesquiterpenes main compounds in oil. Antibacterial, antifungal, antiviral, antiemetic, and anti-inflammatory activities just a few of many pharmacological actions that well-known. In this investigation, cefuroxime (CEF), moxifloxacin (MOX), clarithromycin (CLA), fluconazole (FLU), terbinafine (TER) were combined with (Pogostemon leaf oil). Gram-positive Staphylococcus aureus ATCC 6538, Gram-negative Escherichia coli 8739, yeasts Candida albicans 10231, C. tropicalis 750 tested against all combinations. Drug interaction was given as fractional inhibitory concentrations (FIC) after combinations oils for their minimum (MIC). The checkerboard method assess antimicrobial interactions, Fluconazole, terbinafine, cefuroxime, demonstrated an "additive effect" strains together E. S. aureus.